主要职责:

主要职责 / Key Responsibilities

一、工艺开发与优化 / Process Development & Optimization

负责哺乳动物/微生物细胞培养工艺开发与优化，包括培养基筛选、工艺参数研究、代谢调控等；
Responsible for mammalian/microbial cell culture process development and optimization, including media screening, process parameter studies, and metabolic regulation.
主导小试/中试规模生物反应器（如STR、WAVE）的工艺开发及DOE实验设计；
Lead lab/pilot-scale bioreactor (e.g., STR, WAVE) process development and DOE experimental design.

二、技术转移与项目申报 / Technology Transfer & Regulatory Submissions

建立完整的工艺开发技术文档（批记录、SOP、技术报告），支持IND/BLA申报；
Establish comprehensive technical documentation (batch records, SOPs, technical reports) to support IND/BLA submissions.
参与技术转移至GMP生产部门，解决放大生产中的工艺问题；
Participate in technology transfer to GMP manufacturing departments and resolve process-related issues during scale-up.

三、平台建设与管理 / Platform Development & Management

跟踪国内外细胞培养技术动态，评估新技术在工艺开发中的应用潜力；
Monitor domestic and international technological trends in cell culture, and evaluate the potential application of new technologies in process development.
负责仪器的日常维护及其他细胞培养工艺开发相关的工作；
Oversee daily instrument maintenance and other tasks related to cell culture process development.

任职资格：

教育背景：

硕士及以上学历，生物工程、生物技术、发酵工程等相关专业。
Master’s degree or above in Bioengineering, Biotechnology, Fermentation Engineering, or related disciplines.

相关经验：

课题涉及细胞实验，熟悉CHO/HEK293等表达系统。
Research projects involving cell culture experiments, with familiarity in CHO/HEK293 expression systems.

语言要求：

具备良好的英语听说读写能力，能够流畅阅读英文专业文献，与国际同行进行技术交流。
Strong English proficiency (listening, speaking, reading, writing), capable of fluently interpreting English technical literature and conducting technical communication with international peers.

预期工作地点：

上海/苏州/广州/连云港

Shanghai / Suzhou / Guangzhou / Lianyungang

能力要求：

专业技能：

掌握细胞培养、无菌操作等基础实验技能（有CHO/HEK293培养经验优先）；参与过细胞培养相关科研课题（如培养基优化、代谢流分析）优先；Proficient in fundamental experimental techniques (e.g., cell culture, aseptic operations); Priority given to candidates with CHO/HEK293 culture experience or involvement in cell culture-related research projects (e.g., media optimization, metabolic flux analysis).
了解生物反应器工作原理，有摇床/小型生物反应器操作经验，熟悉生物反应器控制系统或自动化设备操作优先；Understanding of bioreactor operating principles; Preference for candidates with hands-on experience in shaker flasks/small-scale bioreactors or familiarity with bioreactor control systems/automated equipment.
具备基础数据处理能力（Excel/JMP/Minitab）；Basic data analysis capabilities (Excel/JMP/Minitab).
发表过相关领域SCI论文或专利优先。 Priority given to candidates with publication of SCI-indexed papers or patents in relevant fields.

通用能力：

学习能力强，对生物制药工艺开发有浓厚兴趣；Strong learning agility and deep interest in biopharmaceutical process development.
逻辑清晰，具备独立解决问题能力；Logical thinking and independent problem-solving skills.
具备良好的跨部门协作意识。Strong cross-departmental collaboration mindset.